Endothelial Research Centre | University of Tartu

PUBLICATIONS

.2022

Paapstel K, Kals J. Metabolomics of Arterial Stiffness. Metabolites 2022;12(5):370. doi: 10.3390/metabo12050370.

2021

Pauklin P, Eha J, Tootsi K, Kolk R, Paju R, Kals M, Kampus P. Atrial fibrillation is associated with increased central blood pressure and arterial stiffness. J Clin Hypertens (Greenwich) 2021;23(8):1581-1587. doi: 10.1111/jch.14323.
Kuusik K, Kasepalu T, Zilmer M, Eha J, Vähi M, Torop LA, Lieberg J, Kals J. The role of RIPC in preventing organ damage, inflammation and oxidative stress during lower limb DSA: a randomised controlled trial. Oxid Med Cell Longev. 2021 8;2021:6043550. doi: 10.1155/2021/6043550.
Lieberg J, Wanhainen A, Ottas A, Vähi M, Zilmer M, Soomets U, Björck M, Kals J. Metabolomic Profile of Abdominal Aortic Aneurysm. Metabolites 2021;11(8):555. doi: 10.3390/metabo11080555.
Jürgenson J, Serg M, Kampus P, Kals J, Zagura M, Zilmer K, Zilmer M, Eha J, Unt E. Effect of Half-Marathon Running on Arterial Stiffness and Blood Biomarkers in High-Level and Recreational Male Athletes. J Sports Sci Med. 2021;20(4):548-556. doi: 10.52082/jssm.2021.548.

2020

Teeäär T, Serg M, Paapstel K, Vähi M, Kals J, Cockcroft JR, Zilmer M, Eha J, Kampus P. Atenolol’s Inferior Ability to Reduce Central vs Peripheral Blood Pressure Can Be Explained by the Combination of Its Heart Rate-Dependent and Heart Rate-Independent Effects. Int J Hypertens. 2020;2020:4259187. doi: 10.1155/2020/4259187.
Tootsi K, Vilba K, Märtson A, Kals J, Paapstel K, Zilmer M. Metabolomic Signature of Amino Acids, Biogenic Amines and Lipids in Blood Serum of Patients with Severe Osteoarthritis. Metabolites. 2020; 8;10(8):323. doi: 10.3390/metabo10080323.
Kasepalu T, Kuusik K, Lepner U, Starkopf J, Zilmer M, Eha J, Vähi M, Kals J. Remote ischaemic preconditioning attenuates cardiac biomarkers during vascular surgery: a randomised clinical trial. Eur J Vasc Endovasc Surg. 2020;59(2):301-308. doi: 10.1016/j.ejvs.2019.09.502.
Kasepalu T, Kuusik K, Lepner U, Starkopf J, Zilmer M, Eha J, Vähi M, Kals J. Remote ischaemic preconditioning influences the levels of acylcarnitines in vascular surgery: a randomised clinical trial. Nutr Metab (Lond). 2020;17:76. doi: 10.1186/s12986-020-00495-3.
Kasepalu T, Kuusik K, Lepner U, Starkopf J, Zilmer M, Eha J, Vähi M, Kals J. Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial. Oxid Med Cell Longev. 2020:7098505. doi: 10.1155/2020/7098505.
Kepler T, Kuusik K, Lepner U, Starkopf J, Zilmer M, Eha J, Vähi M, Kals J. Remote Ischaemic Preconditioning Attenuates Cardiac Biomarkers During Vascular Surgery: A Randomised Clinical Trial. Eur J Vasc Endovasc Surg. 2020;59(2):301–308. doi:10.1016/j.ejvs.2019.09.502.

2019

Kuusik K, Kepler T, Zilmer M, Eha J, Vähi M, Kals J. Effects of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Lower Limb Angiographic Procedures: A Randomised Clinical Trial. Eur J Vasc Endovasc Surg. 2019;58(6):875–882. doi:10.1016/j.ejvs.2019.06.004.
Kepler T, Kuusik K, Lepner U, Starkopf J, Zilmer M, Eha J, Vähi M, Kals J. The Effect of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Vascular Surgery: A Randomised Clinical Trial. Eur J Vasc Endovasc Surg. 2019;57(6):868–875. doi:10.1016/j.ejvs.2018.12.002.
Jürgenson J, Serg M, Kampus P, Kals J, Zagura M, Viru M, Zilmer K, Zilmer M, Eha J, Unt E. Oxidative Stress Parameters and Its Associations With Arterial Stiffness in Competitive Powerlifting Athletes After 12-Week Supervised Strength Training. J Strength Cond Res. 2019;33(7):1816–1822. doi:10.1519/JSC.0000000000003067

2018

Teeäär T, Serg M, Paapstel K, Kals J, Kals M, Zilmer M, Eha J, Kampus P. Heart rate reduction decreases central blood pressure in sick sinus syndrome patients with a permanent cardiac pacemaker. J Hum Hypertens 2018; 32(5):377-384. doi: 10.1038/s41371-018-0051-4.
Tootsi K, Kals J, Zilmer M, Paapstel K, Ottas A, Märtson A. Medium- and long-chain acylcarnitines are associated with osteoarthritis severity and arterial stiffness in end-stage osteoarthritis patients: a case-control study. Int J Rheum Dis 2018; 21(6):1211-1218. doi: 10.1111/1756-185X.13251.
Paapstel K, Kals J, Eha J, Tootsi K, Ottas A, Piir A, Jakobson M, Lieberg J, Zilmer M. Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in atherosclerosis. Nutr Metab Cardiovasc Dis 2018; 28(1):44-52. doi: 10.1016/j.numecd.2017.07.011.
Lieberg J, Pruks LL, Kals M, Paapstel K, Aavik A, Kals J. Mortality After Elective and Ruptured Abdominal Aortic Aneurysm Surgical Repair: 12-Year Single-Center Experience of Estonia. Scand J Surg 2018; 107(2):152-157. doi: 10.1177/1457496917738923.

2017

Tootsi K, Märtson A, Kals J, Paapstel K, Zilmer M. Metabolic factors and oxidative stress in osteoarthritis: a case-control study. Scand J Clin Lab Invest 2017; 77(7):520-526.

2016

Paapstel K, Zilmer M, Eha J, Tootsi K, Piir A, Kals J. Early biomarkers of renal damage in relation to arterial stiffness and inflammation in male coronary artery disease patients. Kidney Blood Press Res 2016; 41(4):488–97.
Paapstel K, Kals J, Eha J, Tootsi K, Ottas A, Piir A, Zilmer M. Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients. IJC Metab Endocr 2016; 11:13–18.
Tootsi K; Kals J; Zilmer M; Paapstel K; Märtson A. Severity of osteoarthritis is associated with increased arterial stiffness. Int J Rheumatol 2016; 2016:6402963. doi: 10.1155/2016/6402963.
Tootsi K; Märtson A; Zilmer M; Paapstel K; Kals J. Increased arterial stiffness in patients with end-stage osteoarthritis: a case-control study. BMC Musculoskelet Disord 2016; 17:335. doi: 10.1186/s12891-016-1201-x.
Kaldur T; Unt E; Ööpik V; Zilmer M; Eha J; Paapstel K; Kals J. The acute effects of passive heat exposure on arterial stiffness, oxidative stress and inflammation. Medicina 2016, doi: 10.1016/j.medici.2016.06.001.
Zagura M; Kals J; Paapstel K; Serg M; Kampus P; Eha J; Zilmer M. Response to “Estimation of pulse wave velocity in patients with peripheral artery disease: a word of caution”. Hypertens Res 2016, 39(8):618–619.
Paapstel K, Zilmer M, Eha J, Tootsi K, Piir A, Kals J. Association between fibulin-1 and aortic augmentation index in male patients with peripheral arterial disease. Eur J Vasc Endovasc Surg 2016; 51(1):76–82.

2015

Ilisson J, Zagura M, Zilmer K, Salum E, Heilman K, Piir A, Tillmann V, Kals J, Zilmer M, Pruunsild C. Increased carotid artery intima-media thickness and myeloperoxidase level in children with newly diagnosed juvenile idiopathic arthritis. Arthritis Res Ther 2015; 17:180.
Soveri I, Kals J. Low dialysate potassium and central arterial pressure waveform. Ups J Med Sci 2015; 120(3):207-12.
Zagura M, Kals J, Kilk K, Serg M, Kampus P, Eha J, Soomets U, Zilmer M. Metabolomic signature of arterial stiffness in male patients with peripheral arterial disease. Hypertens Res 2015; 38(12):840-6.

2014

Salum E, Butlin M, Kals J, Zilmer M, Eha J, Avolio AP, Arend A, Aunapuu M, Kampus P. Angiotensin II receptor blocker telmisartan attenuates aortic stiffening and remodelling in STZ-diabetic rats. Diabetol Metab Syndr 2014; 6:57. doi: 10.1186/1758-5996-6-57.
Kaldur T, Kals J, Ööpik V, Zilmer M, Zilmer K, Eha J, Unt E. Effects of heat acclimation on changes in oxidative stress and inflammation caused by endurance capacity test in the heat. Oxid Med Cell Longev 2014; 2014:107137. doi: 10.1155/2014/107137.
Kals J, Lieberg J, Kampus P, Zagura M, Eha J, Zilmer M. Prognostic impact of arterial stiffness in patients with symptomatic peripheral arterial disease. Eur J Vasc Endovasc Surg 2014; 48(3):308-15.
Serg M, Graggaber J, Kampus P, Zagura M, Kals J, Mäki-Petäjä K, Cheriyan J, Zilmer M, Eha J, McEniery CM, Wilkinson IB. Value of haemodynamic profiling to the response of antihypertensive therapy. Artery Res 2014; 8(4):189-196.

2013

Kaldur T, Kals J, Oöpik V, Burk A, Kampus P, Zagura M, Zilmer M, Unt E. Heat acclimation increases arterial elasticity in young men. Appl Physiol Nutr Metab. 2013; 38(9):922-7.
Salum E, Kals J, Kampus P, Salum T, Zilmer K, Aunapuu M, Arend A, Eha J, Zilmer M. Vitamin D reduces deposition of advanced glycation end-products in the aortic wall and systemic oxidative stress in diabetic rats. Diabetes Res Clin Pract 2013; 100:243–249.

2012

Salum E, Kampus P, Zilmer M, Eha J, Butlin M, Avolio AP, Põdramägi T, Arend A, Aunapuu M, Kals J. Effect of vitamin D on aortic remodeling in streptozotocin-induced diabetes. Cardiovasc Diabetol 2012; 11:58. doi: 10.1186/1475-2840-11-58.
Serg M, Kampus P, Kals J, Zagura M, Zilmer M, Zilmer K, Kullisaar T, Eha J. Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension. Scan J Clin Lab Invest 2012; 72:427–432.
Zagura M, Kals J, Serg M, Kampus P, Zilmer M, Jakobson M, Unt E, Lieberg J, Eha J. Structural and biochemical characteristics of arterial stiffness in patients with atherosclerosis and in healthy subjects. Hypertens Res 2012; 35(10):1032−1037.

2011

Salum E, Zilmer M, Kampus P, Kals J, Unt E, Serg M, Zagura M, Blöndal M, Zilmer K, Eha J. Effects of a long-term military mission on arterial stiffness, inflammation markers, and vitamin D level. Int J Cardiol 2011; 151:106–107.
Serg M, Kampus P, Kals J, Zagura M, Muda P, Tuomainen TP, Zilmer K, Salum E, Zilmer M, Eha J. Association between asymmetric dimethylarginine and indices of vascular function in patients with essential hypertension. Blood Press 2011; 20:111–116.
Kampus P, Serg M, Kals J, Zagura M, Muda P, Karu K, Zilmer M, Eha J. Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness in hypertensive patients. Hypertension 2011; 57:1122–1128
Kals J, Zagura M, Serg M, Kampus P, Zilmer K, Unt E, Lieberg J, Eha J, Peetsalu A, Zilmer M. β2-microglobulin, a novel biomarker of peripheral arterial disease, independently predicts aortic stiffness in these patients. Scan J Clin Lab Invest 2011; 71:257–263.
Zagura M, Serg M, Kampus P, Zilmer M, Eha J, Unt E, Lieberg J, Cockcroft J, Kals J. Aortic stiffness and vitamin D are independent markers of aortic calcification in patients with peripheral arterial disease and in healthy subjects. Eur J Vasc Endovasc Surg 2011; 42:689–695.

2010

Zagura M, Serg M, Kampus P, Zilmer M, Zilmer K, Eha J, Unt E, Lieberg J, Kals J. Association of osteoprotegerin with aortic stiffness in patients with symptomatic peripheral arterial disease and in healthy subjects. Am J Hypertens 2010; 23:586–591.

2009

Heilman K, Zilmer M, Zilmer K, Lintrop M, Kampus P, Kals J, Tillmann V. Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes. Diabetes Res Clin Pract 2009; 84(2):168-73.

2008

Kals J, Kampus P, Kals M, Pulges A, Teesalu R, Zilmer K, Kullisaar T, Salum T, Eha J, Zilmer M. Inflammation and oxidative stress are differently associated with endothelial function and arterial stiffness in healthy subjects and in patients with atherosclerosis. Scand J Clin Lab Invest 2008; 68(7):594−601.
Kampus P, Kals J, Pihl E, Zilmer K, Pulges A, Teesalu R, Normal A, Zilmer M. Association between arterial elasticity, C-reactive protein and mazimal oxygen consumption in well-trained cadets during three days extreme physical load: a pilot study. Physiol Meas 2008; 29(4):429−437.

2007

Kampus P, Kals J, Ristimäe T, Muda P, Ulst K, Zilmer K, Salonen RM, Tuomainen TP, Teesalu R, Zilmer M. Augmentation index and carotid intima-media thickness are differently related to age, C-reactive protein and oxidized low-density lipoprotein. J Hypertens 2007; 25:819-825.
Kals J, Kampus P, Kals M, Teesalu R, Zilmer K, Pulges A Zilmer M. Arterial elasticity is associated with endothelial vasodilatory function and asymmetric dimethylarginine level in healthy subjects. Scand J Clin Lab Invest 2007; 67(5):536−544.

2006

Kals J, Kampus P, Kals M, Pulges A, Teesalu R, Zilmer M. Effects of stimulation of nitric oxide synthesis on large artery stiffness in patients with peripheral arterial disease. Atherosclerosis 2006; 185:368-374
Kampus P, Muda P, Kals J, Ristimäe T, Fischer K, Teesalu R, Zilmer M. The relationship between inflammation and arterial stiffness in patients with essential hypertension. Int J Cardiol 2006; 112:46-5.
Kals J, Kampus P, Kals M, Zilmer K, Kullisaar T, Teesalu R, Pulges A, Zilmer M. Impact of oxidative stress on arterial elasticity in patients with atherosclerosis. Am J Hypertens 2006; 19:902-908.

2004

Kampus P, Kals J, Ristimäe T, Fischer K, Zilmer M, Teesalu R. High-sensitivity C-reactive protein affects central haemodynamics and augmentation index in apparently healthy persons. J Hypertens 2004; 22:1133-1139.